Volume 52, Issue 2 p. 234-242

Lack of Association of OPRM1 and ABCB1 Single-Nucleotide Polymorphisms to Oxycodone Response in Postoperative Pain

Dr Stine T. Zwisler MD, PhD

Corresponding Author

Dr Stine T. Zwisler MD, PhD

Clinical Pharmacology, Institute of Public Health, University of Southern Denmark, Odense, Denmark

Department of Anesthesiology and Intensive Care, Odense University Hospital, Odense, Denmark

Department of Anaesthesiology and Intensive Care, Odense University Hospital, Sdr Boulevard 29, DK-5000 Odense C, Denmark; e-mail: [email protected].Search for more papers by this author
Dr Thomas P. Enggaard MD, PhD

Dr Thomas P. Enggaard MD, PhD

Clinical Pharmacology, Institute of Public Health, University of Southern Denmark, Odense, Denmark

Department of Anesthesiology and Intensive Care, Odense University Hospital, Odense, Denmark

Search for more papers by this author
Dr Soeren Mikkelsen MD

Dr Soeren Mikkelsen MD

Department of Anesthesiology and Intensive Care, Odense University Hospital, Odense, Denmark

Search for more papers by this author
Dr Céline Verstuyft PharmD, PhD

Dr Céline Verstuyft PharmD, PhD

Department of Pharmacology, Faculty of Medicine Paris, University Paris—Sud, Paris, France

Search for more papers by this author
Dr Laurent Becquemont MD, Prof

Dr Laurent Becquemont MD, Prof

Department of Pharmacology, Faculty of Medicine Paris, University Paris—Sud, Paris, France

Search for more papers by this author
Dr Soeren H. Sindrup MD, Prof

Dr Soeren H. Sindrup MD, Prof

Department of Neurology, Odense University Hospital, Odense, Denmark

Search for more papers by this author
Dr Kim Brosen MD, Prof

Dr Kim Brosen MD, Prof

Clinical Pharmacology, Institute of Public Health, University of Southern Denmark, Odense, Denmark

Search for more papers by this author
First published: 07 March 2013
Citations: 30

Abstract

Purpose: The aim of the study was to search for an association between the single-nucleotide polymorphisms A118G in OPRM1 and C3435T and G2677T/A in ABCB1 and the analgesic effect of intravenous oxycodone in postoperative pain. Methods: There were 268 patients with postoperative pain after, primarily, thyroidectomy. At given times during the first 24 hours postoperatively, their pain was rated at rest and during activity according to a numeric rating scale (0 = no pain, 10 = worst possible pain) and calculated as pain time area under the curve0–24 hours. A negative answer in a final questionnaire and/or the use of rescue medication categorized a patient as a nonresponder. Results: For OPRM1, there was no difference found between the wild type and the variant allele in the percentages of nonresponders (118AA = 16.4% vs 118AG/118GG = 17.0%, P = 1.0) or in the pain ratings. For ABCB1, no difference was found between the wild type and the variant alleles for single-nucleotide polymorphism tested as percentages of nonresponders (3435CC = 17.5% vs 3435CT/3435TT = 15.8%, P = .85; 2677GG = 17.8% vs 2677GT/2677TT = 15.8%, P = .74) or pain ratings. Conclusion: No association was found between the tested single-nucleotide polymorphisms in OPRM1 and ABCB1 and changes in the analgesic effect of oxycodone.