Volume 53, Issue 3 p. 339-344
Original Article

Prescription of Antiepileptics and the Risk of Road Traffic Crash

Ludivine Orriols PhD

Corresponding Author

Ludivine Orriols PhD

Centre INSERM U897-Epidemiologie-Biostatistique, Univ. Bordeaux, ISPED, Bordeaux, France

INSERM, Equipe Prévention et prise en charge des traumatismes, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France

Corresponding Author:

Ludivine Orriols, PhD, Equipe prévention et prise en charge des traumatismes, Centre de recherche INSERM U897 “Epidémiologie et Biostatistiques” Université Bordeaux Segalen, Case 11, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France.

E-mail: [email protected]

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Alexandra Foubert-Samier MD

Alexandra Foubert-Samier MD

Centre INSERM U897-Epidemiologie-Biostatistique, Univ. Bordeaux, ISPED, Bordeaux, France

INSERM, Equipe Epidémiologie et neuropsychologie du vieillissement cérébral, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France

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Blandine Gadegbeku Msc

Blandine Gadegbeku Msc

Université de Lyon, Lyon, France

IFSTTAR, UMR T 9405, UMRESTTE, Bron, France

Université Lyon 1, UMRESTTE, Lyon, France

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Bernard Delorme MD, PhD

Bernard Delorme MD, PhD

Pôle information des professionnels et du public, Direction de la communication et de l'information, Agence nationale de sécurité du médicament et des produits de santé (ANSM), Saint-Denis, France

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Aurore Tricotel Msc

Aurore Tricotel Msc

Pôle épidémiologie des produits de santé, Direction de la surveillance, Agence nationale de sécurité du médicament et des produits de santé (ANSM), Saint-Denis, France

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Pierre Philip MD, PhD

Pierre Philip MD, PhD

USR CNRS SANPSY 3413, Université Bordeaux Segalen, Bordeaux, France

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Nicholas Moore MD, PhD

Nicholas Moore MD, PhD

INSERM U657, CIC-P0005, Département de Pharmacologie, Université Bordeaux Segalen, Bordeaux, France

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Emmanuel Lagarde PhD

Emmanuel Lagarde PhD

Centre INSERM U897-Epidemiologie-Biostatistique, Univ. Bordeaux, ISPED, Bordeaux, France

INSERM, Equipe Prévention et prise en charge des traumatismes, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France

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on behalf of the CESIR Research Group

on behalf of the CESIR Research Group

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First published: 20 February 2013
Citations: 15

Abstract

Studies assessing the impact of epilepsy and its medication on the risk of road traffic crashes have shown inconsistent results. The aim in this study was to assess this risk using French databases. Data from three French national databases were extracted and matched: the national health care insurance database, police reports, and the national police database of injurious crashes. Only antiepileptics prescribed predominantly in epilepsy were studied (phenobarbital, phenytoin, ethosuximide, valproic acid, vigabatrin, tiagabin, levitiracetam, zonisamide, and lacosamide). A case–control analysis comparing responsible and non-responsible drivers and a case–crossover analysis were performed. Drivers (72 685) involved in an injurious crash in France between July 2005 and May 2008, were included. Drivers exposed to prescribed antiepileptic medicines (n = 251) had an increased risk of being responsible for a crash (OR 1.74 [1.29–2.34]). The association was also significant for the most severe epileptic patients (n = 99; OR = 2.20 [1.31–3.69]). Case–crossover analysis found no association between crash risk and treatment prescription. Patients with prescription of antiepileptic drugs should be cautioned about their potential risk of road traffic crash. This risk is however more likely to be related to seizures than to the effect of antiepileptic medicines.