Browse Editor’s Choice

Editors Choice articles are chosen by the Editor and made freely available to readers for a period of one month

Pharmacokinetics and Safety Assessment of l-Tetrahydropalmatine in Cocaine Users: A Randomized, Double-Blind, Placebo-Controlled Study

Hazem E. Hassan, Deanna Kelly, et al.

Approximately 17 million people worldwide abuse cocaine (cocaine use disorder or CUD). To date, the treatment of CUD has lagged behind that of opioid misuse. This month’s Editor’s Choice article examines the pharmacokinetics and safety of L-Tetrahydropalmatine (L-THP), an plant derived agent under development.... more

PCSK9 Inhibition With Monoclonal Antibodies: Modern Management of Hypercholesterolemia

Matthew K. Ito and Raul D. Santos

PCSK9 inhibitors are the newest class of drugs to treat common dyslipidemias. While statins continue to be the “gold standard” for treatment, some patients either do not tolerate these drugs or do not get sufficient lipid lowering effect from statin. The PCSK9 inhibitors, which are administered via.... more

Proton Pump Inhibitors Are Not Associated With Acute Kidney Injury in Critical Illness

Joon Lee, Roger G. Mark, et al.

This month’s Editor’s choice article examines if the previous use of proton pump inhibitors (PPIs) increase the risk of renal disease in critically ill patients. A recent, well publicized study, suggested that the use of PPIs, some of which are available over the counter, is associated with the development.... more

Pharmacokinetic Properties and Human Use Characteristics of an FDA-Approved Intranasal Naloxone Product for the Treatment of Opioid Overdose

Philip Krieter, Nora Chiang, et al.

The epidemic of opioid use, abuse and overdose continues in many areas of the world. In the USA, many states have made naloxone, an opioid antagonist, available without a prescription. However, naloxone was generally available only as an injectable product. Many first responders and individuals (often.... more

Safety Concerns Surrounding Quinolone Use in Children

Karisma Patel and Jennifer L. Goldman

The use of fluoroquinolones in children, while not controversial among Pediatric clinicians, is often confusing for other clinicians that take care of children. This confusion can lead to children being denied therapies that may be the best antibiotic choice for an infection. This month’s Editor’s choice.... more

Acetylsalicylic Acid Daily vs Acetylsalicylic Acid Every 3 Days in Healthy Volunteers: Effect on Platelet Aggregation, Gastric Mucosa, and Prostaglandin E2 Synthesis

Plinio Minghin Freitas Ferreira, Thiago Gagliano-Jucá, et al.

Aspirin has been used for over a century for a variety of indications. Guidelines suggest using aspirin for a variety of cardiovascular conditions to prevent platelet aggregation. Additionally, recent data suggests that low dose aspirin may also reduce the risk of the development of colon cancer. One.... more