Browse Editor’s Choice

Editors Choice articles are chosen by the Editor and made freely available to readers for a period of one month

Optimization of Maternal Magnesium Sulfate Administration for Fetal Neuroprotection: Application of a Prospectively Constructed Pharmacokinetic Model to the BEAM Cohort

Magnesium sulfate is indicated for neuroprotection of the fetus who is born before 32 weeks gestation.  To date, optimal dosing of magnesium sulfate in the pregnant woman has not been know.  This month’s Editor’s choice article analyzes data from the Beneficial Effects of Antenatal Magnesium Sulfate.... more

Pharmacokinetics of Tedizolid in Obese and Nonobese Subjects

Obesity is an increasing problem worldwide.  This has resulted in confusion on the dosing of drugs in this population.  This month’s Editor’s Choice article examines the dosing of tedizolid in obese and non-obese individuals. The authors showed minor differences between the 2 groups of subjects in terms.... more

Antimuscarinic Use in Females With Overactive Bladder Syndrome Increases the Risk of Depressive Disorder: A 3-Year Follow-up Study

Shiu-Dong Chung, PhD, MD, Sung-Shun Weng, PhD, Chao-Yuan Huang, MD, Herng-Ching Lin, PhD, and Li-Ting Kao, MS

To date, the relationship between antimuscarinics for overactive bladder (OAB) syndrome and depressive disorder still remains unclear. Therefore, this retrospective cohort study examined the association between antimuscarinic use and the subsequent risk of depressive disorder using a population-based.... more

A Simulation Study to Compare the Treatment Effect of Tamoxifen by CYP2D6 Genotypes and Third-Generation Aromatase Inhibitors

Gwan Cheol Park,MS, Jin-A Jung, PhD, Kyun-Seop Bae, MD, PhD, and Hyeong-Seok Lim, MD, PhD

Tamoxifen and aromatase inhibitors have been used as treatment and prevention of estrogen receptor positive breast cancer. Tamoxifen is a prodrug that is converted by the polymorphic enzyme CYP2D6 into its active form, endoxifen.  This month’s Editor’s Choice article examines CYP2D6 genotype and response.... more

Antimuscarinic Use in Females With Overactive Bladder Syndrome Increases the Risk of Depressive Disorder: A 3-Year Follow-up Study

Shiu-Dong Chung, Sung-Shun Weng, et al.

Overactive bladder occurs in 17% of women. In the treatment of overactive bladder, a number of drugs are available that reduce urinary urgency and frequency. However, these drugs, while effective, are not without side effects.  This month’s Editor’s Choice article examines the frequency of depression.... more

Model-Based Dose Selection for Intravaginal Ring Formulations Releasing Anastrozole and Levonorgestrel Intended for the Treatment of Endometriosis Symptoms

Isabel Reinecke, Marcus-Hillert Schultze-Mosgau, et al.

Endometriosis affects many young women, causing pain, dysmenorrhea, and other symptoms that affect the quality of life. Traditional therapy has attempted to reduce estrogen effects through suppression of systemic endogenous production. However, estrogens place an important role in the body including.... more

Allometry Is a Reasonable Choice in Pediatric Drug Development

Tao Liu, Parima Ghafoori and Jogarao V. S. Gobburu

During drug development, children present a challenge in terms of drug dosing. Under the Best Pharmaceuticals for Children Act and the Pediatric Research Equity Act amendment, drug development in children was supported and promoted. This month’s Editor’s Choice article examines the use of allometry.... more