Editor’s Choice

Antimuscarinic Use in Females With Overactive Bladder Syndrome Increases the Risk of Depressive Disorder: A 3-Year Follow-up Study

Overactive bladder occurs in 17% of women. In the treatment of overactive bladder, a number of drugs are available that reduce urinary urgency and frequency. However, these drugs, while effective, are not without side effects.  This month’s Editor’s Choice article examines the frequency of depression in 9760 women receiving antimuscarinic drugs for overactive bladder. The authors found that the incidence of depression was significantly increased in women, over the age range of 18 and greater,  receiving these drugs. The mechanism of this increase in depression is unknown at this time.  The authors recommend that clinicians discuss the potential for depression with women who are given these drugs for overactive bladder.

-- Shiu-Dong Chung, Sung-Shun Weng, et al.,

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