Editor’s Choice

Population Pharmacokinetics and Pharmacodynamics of Meropenem in Nonobese, Obese, and Morbidly Obese Patients

This month’s Editor’s choice article explores the issue of antibiotic dosing in obesity. Obesity is rising globally. Most studies during drug development are performed in people of normal body size (non-obese). However, when the drugs are used in the clinical setting, patients of all body sizes are treated. For antibiotics, some target values have been established to allow for optimizing efficacy while reducing the risk of the development of bacterial resistance. This month’s article examines the pharmacokinetics of meropenem, a broad spectrum carbapenem antibiotic in patients of different sizes. The authors found that most standard dosing regiments reached pharmacodynamics targets in patients of all body sizes studies. However, the authors note that prolonged (3 hour) infusions of meropenem may be desirable to improved target attainment for the drug.

-- Eun Kyoung Chung, S. Christian Cheatham, et al.,